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Disease Description
Multiple sclerosis (MS) is thought to be an autoimmune disease of the central nervous system (brain, spinal cord). The disease attacks myelin, the protective covering of the nerves, causing inflammation and often damaging the myelin. Myelin is necessary for the transmission of nerve impulses through nerve fibres. If damage to myelin is slight, nerve impulses travel with minor interruptions; however, if damage is heavy and if scar tissue replaces the myelin, nerve impulses may be completely disrupted, and the nerve fibres themselves can be damaged.
MS can cause symptoms such as extreme fatigue, lack of coordination, weakness, tingling, impaired sensation, vision problems, bladder problems, cognitive impairment and mood changes. [1]
Prevalence
Disease onset usually occurs in young adults, and it is more common in females. It has a prevalence that ranges between 2 and 150 per 100,000.[2]
Current Treatment Options
No one knows what causes multiple sclerosis and there is no cure, but treatment can manage and relieve symptoms. Treatments attempt to return function after an attack, prevent new attacks, and prevent disability.[2]
Evidence for Cannabinoids
Sativex, an oromucosal spray formulated from both THC and CBD has been approved by many regulatory agencies around the world for the treatment of MS spasticity.
A phase III clinical trial4 investigating the effects of Sativex in over 500 people showed that 48% of participants had 20% or more improvement in their spasticity. Amongst those who responded, about three quarters had an improvement of greater than 30% in their spasticity score within four weeks when compared with those taking a placebo. Combined analysis of three clinical trials confirmed the effectiveness of Sativex5.[3]
Proposed mechanism of Cannabinoid Therapies
The exact mecahnism is unknown but is likely the action of the Cannabinoids on the CB1 and CB2 receptors spread throughout the brain and peripheral body.[3]
1) Multiple Sclerosis Society of Canada
2) WebMD
3) Multiple Sclerosis Trust
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We call this “Compounding our Wealth” through extra spinout share participation for all our loyal GBXI shareholders. Each registered GBXI shareholder will receive additional shares of each spinout Company over and above their original shares to enjoy additional liquidity as each company begins to trade through the GBXI Digital Business HUB spinout process.
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GA Raymond,
My Q is when do we get our 2x shares and the gift shares as i have been giving u money over a year ago?????
Thanks for following up Guys! Two things to Remember.
*** One, this is our in-house audit confirmation records for our Financials. We will sign-off...Thanks for following up Guys! Two things to Remember.
*** One, this is our in-house audit confirmation records for our Financials. We will sign-off on our in-house records, complete our Financials, and send the Financials to the Auditors.
*** Two, our “CSi-VIP Shareholder Legacy Reports” that we send out to our CSi-VIPs include ALL your holdings in the Company line by line. However, for those not becoming a CSi-VIP this requires much more time to complete.
We are trusting your initial information to be accurate, CBIS GIFT Shares recipients will have their shareholding records matched and sent in for your CBIS-Gift Shares, and then they will be confirmed, and matched through the Audit process as well, so we are good.
When the Auditors begin their Audit of our Financials they will confirm random information from our shareholders, brokers, and the transfer agent. I doubt the Auditors will call or email everyone, due to the large numbers, but they will do their random checks.
So yes, please do email your information to audit@cannabisscience.com so all the records are in one spot for the Financials.
If you do nothing we will just go with the records we have on file. So, for your peace of mind please send another email to confirm, if it bothers you too much, don't do it. We are confirming everything in -house three times or more from each time we asked you to send it in. It seems we get more shareholders showing up each time we ask, which is great.
So Again, no one needs to purchase anything extra "if you do not want" all the Original CBIS Shares as well as ALL the “CSi-VIP Bonus Shares”, “CSi-Award Shares” and “CBIS-GIFT Shares” will be included in the Financials and Registration Statement to become free trading with the new trading symbol.
They are ALL Common Class Shares the same as the Original CBIS Shares so the final list will be derived from all the past shareholder records on file with the brokerage firms, the transfer agent, and Company in-house records combined.
While we are confirming we have allowed shareholders to acquire their CSi-VIP Status, their GIFT-Shares, and CSi-VIP Bonus Shares to increase their shareholder holdings, smart move Guys! and Congrats!
We have been quite busy working in an order of Priority, so we are behind with the CSi-VIP Legacy Shareholder Reports, but they are certainly ALL on the books of the Company and being done in-between phone calls and progress, so ALL our CSi-VIP, CSi-Award, and CBIS GIFT Shares are on Record, so you are good.
Hopefully this helps, I think it will help based on the questions I get in the appointments, this information will most likely be included in the next UPDATE Email we send out as well, so you are reading it beforehand as we try to stay ahead of the curve.
All the Best Guys! and Congrats! Once again to ALL our Shareholders as we navigate through the final steps to get our shares trading again!
May God Bless us all.
Talk soon.
Raymond - IGWT
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