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Disease Description
Type 2 diabetes mellitus is a disorder affecting the way your body uses glucose (sugar). Cells in your body need sugar to work normally and sugar gets into the cells with the help of the hormone called insulin. Without enough insulin, or if the body stops responding to insulin, sugar builds up in the blood.[1]
In type 2 diabetes mellitus, the pancreas does not make enough insulin, the body becomes resistant to normal or even high levels of insulin, or both. This causes high blood glucose (blood sugar) levels, which can cause serious problems if untreated.[1]
Type 2 diabetes is a medical condition that requires regular monitoring and treatment throughout your life. Fortunately, with proper treatment one can keep blood sugar levels close to normal and minimize the risk of developing complications.[1]
Prevalence
In 2012, 29.1 million Americans, or 9.3% of the population, had diabetes. Diabetes remains the 7th leading cause of death in the United States in 2010, with 69,071 death certificates listing it as the underlying cause of death, and a total of 234,051 death certificates listing diabetes as an underlying or contributing cause of death. In the United States, Canada, and Europe, about 90 percent of all people with diabetes have type 2 diabetes.[2]
Current Treatment Options
Treatment includes lifestyle changes, self-care measures, and sometimes medications.A number of oral medicines (pills) are available to treat type 2 diabetes. [2]
Metformin — Most people who are newly diagnosed with type 2 diabetes will immediately begin a medicine called metformin (Glucophage, Glumetza, Riomet, Fortamet). Metformin improves how your body responds to insulin to reduce high blood sugar levels.[2]
Insulin — In the past, insulin treatment was reserved for patients with type 2 diabetes whose blood sugars were not controlled with oral medicines and lifestyle changes. However, there is increasing evidence that using insulin at earlier stages may improve overall diabetes control and help to preserve the pancreas's ability to make insulin.[2]
There are a number of additional medications on the market. You should consult with your health care provider to see which medications are right for you.
Evidence for and Proposed Mechanism for Cannabinoid Therapies
The study of the role of the endocannabinoids and their receptors in food intake and energy balance led, only little more than a decade after the identification of the endocannabinoid signaling system, to the development of several new therapeutic drugs. However due to unwanted side effects these drugs were eventually removed from the market.[3]
Rather than global obesity, often associated with depressive disorders, the indication novel cannabinoid compounds, as well as of other strategies aiming at reducing endocannabinoid overactivity, should be instead for those metabolic dysfunctions that are associated with abdominal obesity. For example, the administration of second-generation CB1 receptor antagonists to moderately obese patients is likely to improve considerably the benefit/risk ratio of these compounds and result in long-term beneficial outcomes on type 2 diabetes.[3]
1) UpToDate online resource
2) American Diabetes Association
3) Mechoulam et al. Cannabinoids and Endocannabinoids in Metabolic Disorders with Focus on Diabetes
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Category
Critical Ailments -
Created
Thursday, 16 March 2017 -
Group admin
CBIS
American States University
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ALL of your PREVIOUS Cannabis Science (CBIS) Shares are on Record with the Company and with the Transfer Agent (As Confirmed by the SEC).
The Company does NOT have your Original trading CBIS Shares, either you have them, or your Brokerage Firm has them (with new identifier codes) or the Transfer Agent has them.
You can confirm with your Broker (Please obtain an Official Brokerage Firm Letter Representing where your CBIS shares are).
Your CBIS GIFT Shares are on Record Books with the Company and/or in your possesion for Regulatory submissions, Registered Legal Opinion Letters, and awaiting Final Audit for Final Trading approvals.
Your CBIS Shares are legal tender and we are ALL waiting for the FINAL Confirmations for trading once the Audits and Legal Filings are completed.
*** We will announce the FINAL CBIS acquisition changes and Corporate Mergers once the filings are completed, so as long as you know where your CBIS Shares are, you are GOOD.
As clearly stated by Mr. Dabney "Our History is Building up into our Inaugural Event of our Lifetime, the Inaugural 1-Million Strong Killing Cancers, Fight Club, VIP Fundraiser Event, dubbed, 'Celebrities Raising $20 Million to Keep Killing Cancers' the Initiative is fueled further with the '1- Million Strong Killing Cancers, Variety Television Show' through the ASU 'Make that Change Campaign'. Hence the accumulation of 1-Million people donating $20 each, because we are ALL Celebrities in our own Rights.
This is More than enough Funding to begin our FDA Clinical Trials for our 'Low-Cost Cancer Drugs' to treat millions Worldwide that already has proven HARVARD Award Winning Cancer Killing Success!
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This is also PLENTY of Funding to bring ALL our CBIS Shares back trading again and follow through with our Original Complete Cannabis Science Share trading Game Plan, and We Win, once again. Hopefully we'll see you at the Event to help 'Make that Change'!"
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The ASU Digital Business HUB will be used as the main business student learning center. GBXI will be the main pivot point to spin out trading shares of all our Partner Public and Private Companies such as Cannabis Science, iCannabinoid, Thermic Science, LNC, LMG, and a few more old and new school surprises for our loyal shareholders. No one will be missed! A true Digital Business HUB for students, just as planned all along.
Each spinout company will give our GBXI registered shareholders additional pro-rata shares in each spinout company over and above their original shares in each entity. This provides the required shareholder base for each company required to trade and gives additional shares to all our loyal GBXI shareholders.
We call this “Compounding our Wealth” through extra spinout share participation for all our loyal GBXI shareholders. Each registered GBXI shareholder will receive additional shares of each spinout Company over and above their original shares to enjoy additional liquidity as each company begins to trade through the GBXI Digital Business HUB spinout process.
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