DIsease Description
Chronic Pain is a very broad medical disorder comprised of many different pain syndromes and underlying reasons for the symptoms[1]. Pain is influenced by many different elements other than physical neural inputs including the brain, emotional and social factors. As a result acute pain differs from chronic pain and cancer related pain differs from non-malignant pain, making comparison between these different groups important when determining what treatment to use[2].
The International Association for the Study of Pain defines chronic pain as pain persisting beyond the normal tissue healing time (3 - 6 months) [3]. Chronic pain is associated with an abnormal neuron responsiveness or increased gain of nerve pathways to the brain, as well as with alterations in the brains interpretation of the signals[2].
In this group we are specifically referring to chronic pain that is not a result of cancer.
Disease Prevelance
The prevalence of non-specific chronic pain in the general population is reported to be as high as 55%[4,5].
Current Treatment Options
Chronic pain remains a very task for today's doctors due to a lack of effective treatments. Controversially opioids have been and continue to be regularly prescribed in chronic pain treatment. There are very serious concerns about their long-term effectiveness and the major issue of addiction [6]. Evidence suggests that in some patients long term opioid exposure may actually worsen a patients pain[2].
Evidence for and Proposed Mechanism of Action of Cannabinoid Therapeutics
In a study in Spain, the evidence that pain states alter the endocannabinoid receptor system at key sites involved in pain processing is discussed, and how the changes may inform the development of cannabinoid-based analgesics. According to this study, "cannabinoid ligands produce well documented analgesic effects mediated by the CB1 and CB2 receptors; however, other receptor systems may also contribute, in particular in inflammatory and neuropathic pain states. The emerging evidence that the levels of cannabinoid receptors, their ligands and biologically active metabolites are altered in a tissue-specific manner under pathological conditions, such as chronic pain states, may support a more targeted approach to the development of cannabinoid-based analgesics."[8]
There has been a lot of encouraging research surrounding the issue of cannabinoid treatments for chronic pain. Animal studies using either acute or chronic pain models have demonstrated significant pain relieving effects of Cannabinoids. However, the role of CBs in human analgesia or antihyperalgesia is less well documented [7].
In a systematic review by De Vries et a. it was stated that, "The introduction of CB (cannabinoid) medicines offers an interesting alternative approach in the area of chronic pain management, particularly for cases in which currently available pharmacological treatments are not sufficient. Scientific literature on clinical research regarding medicinal CBs lags far behind the extensive anecdotal experiences of both patients and their physicians. The majority of clinical trials in patients with chronic non-malignant pain summarized in this review reported improvement in pain scores in favor of products containing dronabinol."[2] 1. Beaulieu P, Ware M. Reassessment of the role of cannabinoids in the management of pain. Curr Opin Anaesthesiol 2007;20(5):473-7
2. de Vries et al. Dronabinol and chronic pain: importance of mechanistic considerations. Expert Opin. Pharmacother. (2014) 15(11):1525-1534
3. Merskey H, Bogduk N. Classification of chronic pain: descriptions of chronic pain syndromes and definitions of pain terms. 2013. International Association for the Study of Pain (IASP), Task Force on Taxonomy, Seattle 1994
4. Andersson HI, Ejlertsson G, Leden I, Rosenberg C. Chronic pain in a geographically defined general population: studies of differences in age, gender, social class, and pain localization. Clin J Pain. 1993;9(3):174-82.
5. Elliott AM, Smith BH, Penny KI, Smith WC, Chambers WA. The epidemiology of chronic pain in the community. Lancet. 1999 Oct; 354(9186):1248-52.
6. Noble M, Tregear SJ, Treadwell JR, Schoelles K. Long-term opioid therapy for chronic noncancer pain: a systematic review and meta-analysis of efficacy and safety. J Pain Symptom Manage 2008;35(2):214-28
7. Karst M, Wippermann S, Ahrens J. Role of cannabinoids in the treatment of pain and (painful) spasticity. Drugs 2010;70(18):2409-38
8. Sagar, Devi Rani et al. “Dynamic Regulation of the Endocannabinoid System: Implications for Analgesia.” Molecular Pain 5 (2009): 59. PMC. Web. 20 Nov. 2014.
Recent GBXI News:
May 11, 2023, GBX International Group, Inc., (OTC: GBXI)
GBX International Group, Inc. (OTC:GBXI) Confirms 2023 Strong Revenue Growth Guidance Projections by Combining Each Acquired Operating Company Product Release, Expects Strong Growth Sector by Sector Through its Multiple Product Releases into North American and International Markets
April 21, 2023, GBX International Group, Inc., (OTC: GBXI)
HARVARD Award Winning Entrepreneur, Mr. Raymond C. Dabney Acquires Majority Shareholder Control of GBX International Group, Inc. (OTC: GBXI) Makes More History Bringing CSi-EDP Partner American States University (ASU) as the First Acquisition for its Aggressive Growth Plans
The ASU Digital Business HUB will be used as the main business student learning center. GBXI will be the main pivot point to spin out trading shares of all our Partner Public and Private Companies such as Cannabis Science, iCannabinoid, Thermic Science, LNC, LMG, and a few more old and new school surprises for our loyal shareholders. No one will be missed! A true Digital Business HUB for students, just as planned all along.
Each spinout company will give our GBXI registered shareholders additional pro-rata shares in each spinout company over and above their original shares in each entity. This provides the required shareholder base for each company required to trade and gives additional shares to all our loyal GBXI shareholders.
We call this “Compounding our Wealth” through extra spinout share participation for all our loyal GBXI shareholders. Each registered GBXI shareholder will receive additional shares of each spinout Company over and above their original shares to enjoy additional liquidity as each company begins to trade through the GBXI Digital Business HUB spinout process.
Click here to review the Report:
Case No. 2:17-CV-02271-KJM-JDP
Inspire, Dream, Change
YOUR DIGITAL ERA Personal & Business Access Learning HUB
Hello Raymond,
Anything new and exciting for to report on our progress? Curious minds want to know! We should start trading soon I would hope...Hello Raymond,
Anything new and exciting for to report on our progress? Curious minds want to know! We should start trading soon I would hope. Always forward my friend
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Hi Raymond,
As a long-standing Loyal Shareholder, I hope that this posting finds you in good health and good spirits. I made my first CBIS purchase...Hi Raymond,
As a long-standing Loyal Shareholder, I hope that this posting finds you in good health and good spirits. I made my first CBIS purchase in Sept 2014 (Dr. Bob was still at CBIS) and I made my last purchase in June 2017; just prior to the Hemp Seizure that F'k-up everything for CBIS going forward.
BUT, on 2017-01-09 CBIS Entered into 1 yr. Research Collaboration Agreement (RCA) with Dana Farber Cancer Institute (DFCI) to Develop Cannabinoid-Based Medications and Associated Delivery Technologies for the Treatment of Cancers.
Then on 2018-01-18 1st Frontiers In Oncology Article: "Nano Particle Drone to Target Lung Cancer with Radio Sensitizers & Cannabis." - KILLING CANCER
And then again on 2018-02-02 CBIS expanded the RCA with DFCI for 5 yrs. (@ $1.8M) to develop Cannabinoid-Based Medications and Associated Delivery Technologies for the Treatment of Cancers. That RCA agreement expired on 2023-02-02.
NOW, On 2023-02-02 the Expanded RCA with DFCI has ended. THE RESULTS ARE NOW KNOWN:
For the $1.8mil investment with DFCI, several Cancer Killing Formulations have been developed.
#1-6 Represents the drug formulations developed by DFCI during the 5yr RCA for treatment of the following cancers:
1. Skin Cancer
2. Breast Cancer
3. Brain Cancer
4. Kaposi's Sarcoma
5. Lung Cancer
6. Pancreatic Cancer
7. CBN Patent Valuation
#7 is the US Patent that was awarded to CBIS which describes the formulation used to treat certain neurological ailments such as ODD, ADD, etc.
On 2023-05-08 it was announced that GBXI signs the first 3 acquisitions for the GBXI Conglomerate (follow link below for details)
finance.yahoo.com/news/gbxi-advances-forward-signs…
Then On 2023-12-13 you posted the following: "GBXI Corporate Filings, Financials, and trading status has been delayed due to change of control filings and approvals. The Company has several options on the list for trading resumption as it pursues its regulatory approvals. The Company is pursuing the fastest path to trading first and will proceed down the list as it moves towards its ultimate goal of bringing all the GBXI conglomerate company shares back trading again.
QUESTION: Where are we toward the completion of this process?? 50% / 75% / 90% ????
--------
Some info that the I have found about a SPAC is as follows:
When does a SPAC become public?
--------------------------------------------
These types of transactions, most commonly where a SPAC acquires or merges with a private company, occur after, often many months or more than a year after, the SPAC has completed its own IPO. Unlike an operating company that becomes public through a traditional IPO, however, a SPAC is a shell company when it becomes public.
Period to consummate the initial business combination.
--------------------------------------------------------------------
A SPAC will typically provide for a two-year period to identify and complete an initial business combination transaction. However, some SPACs have opted for shorter periods, such as 18 months. The SPAC’s governing instruments may permit it to extend that time period. If a SPAC seeks to extend the time period, it may be required to seek shareholder approval. If a SPAC lists its securities on an exchange, it is required to complete an initial business combination within three years of its IPO. IPO proceeds are held in the trust account until a SPAC consummates a business combination or liquidates. If the SPAC is liquidated, shareholders at the time of the liquidation will be entitled to their pro rata share of the aggregate amount then on deposit in the trust account.
On 2023-11-08 an independent entity named Capizate, Inc.; prepared and presented a "Situation Analysis of the GBX International Group" which provided a list of Strengths, Areas of Improvements, and a Cancer Drug Valuation of just one of the drug formulations noted above ($25Mil-$29Mil) - Impressive.
However, here is the list that I have concern for; can't go PUBLIC without being fixed:
Areas for improvement
----------------------------
1. The business documents, agreements, term sheets, engagements are all dated in 2017-2018 and need to be updated.
2. Ownership and control of the intellectual property needs to be defined and confirmed.
3. A similar entity has active registration with California Secretary of State. The Company has a different address than on the Company website and also had a Statement of Info due to the California Secretary of State on 05/10/2023. Registered with the California Secretary of State as a Non-Profit Nonprofit Corporation - CA - Mutual Benefit. This will need to be defined.
QUESTIONS:
---------------
(1) Who's working on updating documentation? What's the % complete?
(2) Who owns and/or controls the CBIS Intellectual Property?
(3) is there another entity out there using the same name as Cannabis Science?
(4) WHERE IS BRINGING CBIS BACK PUBLIC AGAIN ON YOUR LIST OF PRIORITIES?
Thank you Raymond in advance of your response.
Best Regards
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Cannabis Science CEO, Presents …
The FINAL “CBIS GIFT Shares” Issuances!
DECEMBER 1, 2022, Cheers! & HAPPY HOLIDAYS !!!
ALL GIFT Shares 1, 2, & 3 being ISSUED !!!
LAST Steps:
Please confirm Yours NOW !!!
1. CONFIRM Correct Total Share Amount(s)
2. CONFIRM Correct Name(s) on CERTIFICATE
3. CONFIRM Correct Mailing Address
ASU/CSi-EDP-ECO-System
At it's FINEST !!!
WHICH ONE ARE YOU ??
Those who, MAKE things happen.
Those who WATCH things happen.
Those who WONDER what the ... HAPPENED ???
We can make this HAPPEN way FASTER Working as a TEAM !!!
WHAT Matters is how much you CARE about KILLING CANCERS ...
This is it ... We are ALL Here ... Now ... with a Bunch of Celebrities going on TV Worldwide to Start raising $20 Million to Keep Killing Cancers.
2023 Audit considerations NASDAQ.
Cannabis Science Inc.
Share Structure 2023
Par Value: $0.001 USD
Last Price: $0.00647 USD
OTC Markets.
Common Stock:
Authorized:
5,000,000,000
Issued:
2,521,095,296
Class A Common Stock
Authorized:
100,000,000
Issued:
0
Class B Common Stock
Authorized:
1,500,000,000
Issued:
0
Preferred Stock
Authorized:
1,000,000
Issued:
1,000,000
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