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Disease Description
Basal cell carcinoma's (BCC) are abnormal, uncontrolled growths or lesions that arise in the skin’s basal cells. Basal cells are cells which line the outermost layer of the skin. BCCs often have the appearance of open sores, red patches, pink growths, shiny bumps, or scars. They are usually caused by a combination of cumulative UV light exposure and intense, occasional UV light exposure. BCC’s can be highly disfiguring if allowed to grow, but almost never spreads (metastasizes) beyond the original tumor site to become a life threatening disease. [1]
Prevalence
Estimates of the incidence of BCC are imprecise since there is no cancer registry that collects data on BCC. The American Cancer society estimates that more than two million nonmelanoma skin cancers were treated in the United States in 2006, of which the majority would have been BCC [2]
Current Treatment Options
For superficial low-risk Basal Cell Carcinoma lesions treatment options include surgical excision, or topical treatment with topical 5-fluorouracil or imiquimod.[3]
Evidence for and the Proposed Mechanism for Cannabinoid Threapies
Accumulating recent evidence implicates the endocannabinoid system in the regulation of growth of skin cells. Casanova et al. have demonstrated that various human skin tumors (e.g. basal cell carcinoma, squamous cell carcinoma) express cannabinoid receptors both CB1 and CB2. Local administration of synthetic CB1 and CB2 agonists induced growth inhibition of malignant skin tumors in mice. This growth inhibition was accompanied by enhanced intra-tumor cell death and impaired tumor vascularization (altered blood vessel morphology, decreased expression of pro-angiogenic factors such as VEGF, placental growth factor and angiopoietin 2) [4]
1. Skin Cancer Foundation. www.skincancer.org/
2. American Cancer Society Cancer Facts and Figures 2010.
3. UpToDate Online resources. Uptodate.com
4. Pacher, P. et al. The endocannabinoid system of the skin in health and disease: novel perspectives and therapeutic opportunities. Trends Pharmacol Sci. Aug 2009; 30(8): 411–420.
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Category
Critical Ailments -
Created
Thursday, 16 March 2017 -
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CBIS
American States University
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