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Disease Description
Type 1 diabetes mellitus is a medical condition that occurs when the pancreas, an organ in the abdomen, produces very little or no insulin. Insulin, a hormone that helps the body to absorb and use glucose (sugar). Without insulin, blood glucose levels become higher than normal.
Type 1 diabetes mos often develops when the immune system destroys the insulin-producing cells (beta-cells) in the pancreas. This is called an autoimmune response. The cause of this abnormal immune response is still not completely understood.
This process can take time to occur, and initially there may be no symptoms of diabetes. High blood sugar and its associated symptoms (frequent urination, thirst) do not usually occur until more than 90 percent of the cells that make insulin have been destroyed. . Type 1 diabetes usually begins in childhood or young adulthood, but can develop at any age.
Type 1 diabetes can develop in people with a family history of type 1 diabetes, but it also develops in people with no family history of diabetes. In either case, people who develop diabetes have one or more genes that make them susceptible to the disease. Environmental factors, such as exposure to certain viruses and foods early in life, might trigger the autoimmune response. [1]
Prevalence
In 2012, 29.1 million Americans, or 9.3% of the population, had diabetes. Diabetes remains the 7th leading cause of death in the United States in 2010. In the United States, Canada, and Europe, type 1 diabetes accounts for 5 to 10 percent of all cases of diabetes [1]
Current Treatment Options
Insulin treatment is one component of a diabetes treatment plan for people with type 1 diabetes. Insulin treatment replaces the body's own insulin, and aims to restore normal or near-normal blood sugar levels. With a little extra planning, people with diabetes who take insulin can lead a full life and keep their blood sugar under control.[1]
Evidence for and Proposed Mechanism for Cannabinoid Therapies
It was found that CBD treatment of 6- to 12-week-old mice significantly reduces the incidence of diabetes from 86% in nontreated control mice to 30% in CBD-treated mice. Results indicated that CBD can inhibit and delay destructive insulitis and inflammatory Th1-associated cytokine production in mice, resulting in a decreased incidence of diabetes possibly through an immunomodulatory mechanism shifting the immune response.[2] Research strengthens the previous assumption that CBD, known to be safe in humans, can possibly be used as a therapeutic agent for treatment of type 1 diabetes.[2]
1. UpToDate online resource
2. Weiss L, Zeira M, Reich S et al (2006) Cannabidiol lowers incidence of diabetes in non-obese diabetic mice. Autoimmunity 39:143–151
Recent GBXI News:
May 11, 2023, GBX International Group, Inc., (OTC: GBXI)
GBX International Group, Inc. (OTC:GBXI) Confirms 2023 Strong Revenue Growth Guidance Projections by Combining Each Acquired Operating Company Product Release, Expects Strong Growth Sector by Sector Through its Multiple Product Releases into North American and International Markets
April 21, 2023, GBX International Group, Inc., (OTC: GBXI)
HARVARD Award Winning Entrepreneur, Mr. Raymond C. Dabney Acquires Majority Shareholder Control of GBX International Group, Inc. (OTC: GBXI) Makes More History Bringing CSi-EDP Partner American States University (ASU) as the First Acquisition for its Aggressive Growth Plans
The ASU Digital Business HUB will be used as the main business student learning center. GBXI will be the main pivot point to spin out trading shares of all our Partner Public and Private Companies such as Cannabis Science, iCannabinoid, Thermic Science, LNC, LMG, and a few more old and new school surprises for our loyal shareholders. No one will be missed! A true Digital Business HUB for students, just as planned all along.
Each spinout company will give our GBXI registered shareholders additional pro-rata shares in each spinout company over and above their original shares in each entity. This provides the required shareholder base for each company required to trade and gives additional shares to all our loyal GBXI shareholders.
We call this “Compounding our Wealth” through extra spinout share participation for all our loyal GBXI shareholders. Each registered GBXI shareholder will receive additional shares of each spinout Company over and above their original shares to enjoy additional liquidity as each company begins to trade through the GBXI Digital Business HUB spinout process.
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Case No. 2:17-CV-02271-KJM-JDP
Inspire, Dream, Change
YOUR DIGITAL ERA Personal & Business Access Learning HUB
I hope everyone is doing well. Raymond, Francis Cormier wrote a very detailed, informative summery over a month ago. I do not believe his 4 ever...I hope everyone is doing well. Raymond, Francis Cormier wrote a very detailed, informative summery over a month ago. I do not believe his 4 ever important questions have been answered.
(1) Who's working on updating documentation? What's the % complete?
(2) Who owns and/or controls the CBIS Intellectual Property?
(3) is there another entity out there using the same name as Cannabis Science?
(4) WHERE IS BRINGING CBIS BACK PUBLIC AGAIN ON YOUR LIST OF PRIORITIES?
Can you please elaborate on these for us.
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Hi Raymond,
Per the 3rd party Cancer Drug Valuation(s) Full Report linked from this website:
On November 8, 2023; Capizate, Inc. (a 3rd party entity)...Hi Raymond,
Per the 3rd party Cancer Drug Valuation(s) Full Report linked from this website:
On November 8, 2023; Capizate, Inc. (a 3rd party entity) reported a "Situation Analysis of GBXi" that it performed at GBXI's request; based upon 25 documents provided by GBXI; mostly pertaining to Cannabis Science, Inc. This report included listing: (a) Strengths, (b) Areas for Improvement, (c) CBIS Cancer Drug Valuation(s) [1 specifically], (d) as well as several additional items that supported it giving GBXI a Capitize Score = 623 out of a possible 1000. Getting the potential CBIS Drug Valuation(s) for just 1 drug @ 25Mil-29Mil is/was impressive; however the "Areas for Improvement" are significant:
Areas for improvement
---------------------
1. The business documents, agreements, term sheets, engagements are all dated in 2017-2018 and need to be updated.
2. Ownership and control of the intellectual property needs to be defined and confirmed.
3. A similar entity has active registration with California Secretary of State. The Company has a different address than on the Company website and also had a Statement of Info due to the California Secretary of State on 05/10/2023. Registered with the California Secretary of State as a Non-Profit Nonprofit Corporation - CA - Mutual Benefit. This will need to be defined.
Can you please let us know about the progress that has been made toward resolving these issues?? Even if you could reveal an estimated % complete for each line item that would be nice to see.
The report from November 8, 2023 says: "Your current phase in our process is phase three (Situation Analysis), four (Due Diligence Score), and five (Business Finance Documents – Specifically the analysis) the potential valuation" - out of a 7 phase process; (6) Capital Markets and (7) Post Capitalization. Even if you choose not to continue to use Capitize, Inc. any longer; these "Areas of Improvement" listed MUST BE addressed in order to bring CBIS back Trading again.
Thank you in advance of your response and Best Regards,
...Francis G. Cormier III
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Cannabis Science CEO, Presents …
The FINAL “CBIS GIFT Shares” Issuances!
DECEMBER 1, 2022, Cheers! & HAPPY HOLIDAYS !!!
ALL GIFT Shares 1, 2, & 3 being ISSUED !!!
LAST Steps:
Please confirm Yours NOW !!!
1. CONFIRM Correct Total Share Amount(s)
2. CONFIRM Correct Name(s) on CERTIFICATE
3. CONFIRM Correct Mailing Address
ASU/CSi-EDP-ECO-System
At it's FINEST !!!
WHICH ONE ARE YOU ??
Those who, MAKE things happen.
Those who WATCH things happen.
Those who WONDER what the ... HAPPENED ???
We can make this HAPPEN way FASTER Working as a TEAM !!!
WHAT Matters is how much you CARE about KILLING CANCERS ...
This is it ... We are ALL Here ... Now ... with a Bunch of Celebrities going on TV Worldwide to Start raising $20 Million to Keep Killing Cancers.
2023 Audit considerations NASDAQ.
Cannabis Science Inc.
Share Structure 2023
Par Value: $0.001 USD
Last Price: $0.00647 USD
OTC Markets.
Common Stock:
Authorized:
5,000,000,000
Issued:
2,521,095,296
Class A Common Stock
Authorized:
100,000,000
Issued:
0
Class B Common Stock
Authorized:
1,500,000,000
Issued:
0
Preferred Stock
Authorized:
1,000,000
Issued:
1,000,000
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